Anemia: Sign, symptoms, diagnosis and treatment ( A complete guide). Part 2

This part of the blog focuses on diagnosis and treatment of anemia. Lets get started.

Diagnosing and Treating Anemia

If you have been told that you have anemia, your first question is probably, “What happens next?” The answer depends on why you have anemia. Anemia itself is not a disease—it is a sign that something in your body needs attention. Finding the underlying cause is the most important step because the treatment for one type of anemia may not work for another.

In this blog, we explain how doctors diagnose anemia, the tests you may need, the available treatment options, dietary changes that can help, and practical steps you can take to prevent anemia in the future.

Anemia: Diagnosis

Diagnosing anemia usually begins with a discussion about your symptoms, medical history, and a physical examination. Your doctor may ask questions such as:

How long have you been feeling tired or weak?
Have you noticed dizziness or shortness of breath?
Do you have heavy menstrual periods?
Have you seen blood in your stool, urine, or vomit?
What does your usual diet look like?
Do you have any long-term illnesses such as kidney disease or inflammatory conditions?
Are you taking any medications that may increase the risk of bleeding?

A physical examination may include checking your skin for paleness, examining your nails and tongue, listening to your heart, and feeling your abdomen to assess the liver or spleen.

Blood Tests Used to Diagnose Anemia


Complete Blood Count (CBC)

The Complete Blood Count (CBC) is the most common test used to diagnose anemia.

It measures several components of your blood, including:

Hemoglobin level
Number of red blood cells
Hematocrit (the percentage of blood made up of red blood cells)
Red blood cell size (MCV)
Red blood cell color (MCH and MCHC)
White blood cells
Platelets

A low hemoglobin level confirms anemia. The size of the red blood cells also provides important clues about the cause.

For example:

Small red blood cells often suggest iron deficiency.
Large red blood cells may indicate vitamin B12 or folate deficiency.
Normal-sized red blood cells may be seen in chronic diseases, kidney disease, or recent blood loss.

Iron Studies

If iron deficiency is suspected, your doctor may order:

Serum ferritin
Serum iron
Total iron-binding capacity (TIBC)
Transferrin saturation

Ferritin is especially important because it reflects your body’s iron stores. Low ferritin is one of the earliest and most reliable signs of iron deficiency

Vitamin B12 and Folate Levels

These tests help determine whether anemia is caused by deficiencies in these essential vitamins, which are needed to produce healthy red blood cells.

Reticulocyte Count

Reticulocytes are young red blood cells recently released from the bone marrow.

A high reticulocyte count may indicate that your bone marrow is responding appropriately, such as after blood loss.

A low count may suggest that the bone marrow is not producing enough red blood cells.

Kidney Function Tests ( Renal function tests )

The kidneys produce a hormone called erythropoietin, which stimulates the bone marrow to make red blood cells.

People with chronic kidney disease often develop anemia because they produce less of this hormone.

Other Tests

Depending on your symptoms and age, additional investigations may include:

Stool test for hidden blood
Endoscopy or colonoscopy to look for bleeding in the digestive tract
Tests for celiac disease
Bone marrow examination (in selected cases)
Tests for inherited blood disorders
Screening for chronic infections or autoimmune diseases

Your doctor will recommend only those tests that are appropriate for your situation.

Anemia: treatment

The treatment depends on the cause of the anemia. Simply increasing iron intake is not the answer for every patient.

Treating Iron Deficiency Anemia

Iron deficiency is the most common cause of anemia worldwide.

Treatment usually includes:

Iron-Rich Foods

Increasing iron-rich foods is an important part of recovery.

Foods high in iron include:

Animal Sources (Heme Iron)

These are more easily absorbed by the body.

Lean red meat
Liver (consume in moderation, especially during pregnancy)
Chicken
Turkey
Fish
Shellfish
Plant Sources (Non-Heme Iron)
Lentils
Chickpeas
Beans
Spinach
Kale
Tofu
Pumpkin seeds
Sesame seeds
Dried apricots
Raisins
Fortified breakfast cereals

Although plant sources are healthy, the body absorbs their iron less efficiently than iron from animal foods.

Iron Supplements

Many people with iron deficiency require iron tablets in addition to dietary changes.

Common points to remember include:

Take iron only if it has been recommended by your healthcare provider.
It is often absorbed better on an empty stomach, although taking it with food may reduce stomach upset.
Vitamin C (such as a glass of orange juice) can improve iron absorption.
Avoid taking iron at the same time as tea, coffee, calcium supplements, or dairy products, as they can reduce absorption.

Common side effects includeNausea
Constipation
Stomach discomfort
Dark-colored stools

These side effects are usually temporary and do not mean the treatment is harmful.

Iron Injections

Some people cannot absorb iron tablets or cannot tolerate their side effects.

In these situations, intravenous (IV) iron may be recommended. It is given under medical supervision and can restore iron stores more quickly than tablets.

Vitamin B12 deficiency is treated with:

Vitamin B12 injections
High-dose oral vitamin B12 supplements (in selected patients)
Treatment of the underlying cause if absorption is impaired

Foods rich in vitamin B12 include:

Meat
Fish
Eggs
Milk
Cheese
Yogurt

People following a strict vegan diet may need vitamin B12 supplements because natural plant foods do not provide enough of this vitamin.

Treating Folate Deficiency

Folate deficiency is treated with folic acid supplements and a diet rich in folate.

Foods high in folate include:

Dark green leafy vegetables
Broccoli
Citrus fruits
Beans
Lentils
Peas
Avocados
Fortified grains

Women planning pregnancy should ensure they receive enough folic acid, as it is important for the healthy development of the baby’s brain and spinal cord.

Treating Anemia Caused by Chronic Disease

In these cases, the focus is on treating the underlying illness.

Examples include:

Better control of chronic kidney disease
Managing inflammatory diseases
Treating infections
Treating certain cancers

Some patients with chronic kidney disease may receive medications that stimulate the production of red blood cells.

Blood Transfusions

A blood transfusion is not the standard treatment for most people with anemia.

It is generally reserved for situations such as:

Severe anemia
Significant blood loss
Symptoms affecting the heart or brain
Medical emergencies

A transfusion increases the number of red blood cells quickly, but it does not correct the underlying cause. Further evaluation and treatment are still necessary.

Can Diet Alone Cure Anemia?

It depends on the cause.

If anemia is due to a mild nutritional deficiency, improving your diet may help.

However, many people also require supplements or treatment for the underlying condition.

For example:

A bleeding stomach ulcer must be treated.
Heavy menstrual bleeding may require gynecological evaluation.
Vitamin B12 deficiency caused by poor absorption often requires lifelong replacement.

For this reason, it is important not to self-diagnose or rely solely on dietary changes without medical advice.

Foods That Help Your Body Absorb Iron

Some foods increase iron absorption.

These include:

Oranges
Lemons
Guava
Strawberries
Kiwi
Tomatoes
Bell peppers

These foods are rich in vitamin C, which helps your body absorb iron from plant-based foods more effectively.

Foods That Reduce Iron Absorption

Certain foods and drinks can decrease iron absorption if consumed at the same time as iron-rich meals or iron supplements.

These include:

Tea
Coffee
Calcium supplements
Large amounts of dairy products
High-fiber bran products (when taken with iron supplements)

You do not need to avoid these foods completely. Instead, try to consume them at a different time of day.

Anemia During Pregnancy

Pregnancy increases the body’s demand for iron and folate because the mother is producing more blood and supporting the growth of the baby.

Untreated anemia during pregnancy may increase the risk of:

Premature birth
Low birth weight
Maternal fatigue
Increased risk of blood transfusion if significant bleeding occurs during delivery

Pregnant women should attend regular prenatal visits, eat a balanced diet, and take prenatal vitamins or iron supplements if prescribed.

Anemia in Children

Children need adequate iron for healthy growth and brain development.

Signs of anemia in children may include:

Fatigue
Poor appetite
Pale skin
Delayed growth
Difficulty concentrating
Poor school performance

Parents should avoid giving excessive amounts of cow’s milk to infants and young toddlers, as this may reduce iron intake from other foods. Follow your pediatrician’s guidance on age-appropriate nutrition.

Anemia in Older Adults

Anemia should never be dismissed as a normal part of aging.

In older adults, it may be caused by:

Hidden bleeding from the digestive tract
Nutritional deficiencies
Kidney disease
Chronic inflammatory conditions
Certain medications

Because anemia in older adults can increase the risk of falls, hospitalization, and reduced quality of life, it should always be properly evaluated.

Can Anemia Be Prevented?

Not all types of anemia can be prevented, but many cases can.

Healthy habits include:

Eat a balanced diet with enough iron, vitamin B12, and folate.
Include fruits rich in vitamin C with meals.
Attend regular health check-ups if you have chronic illnesses.
Seek medical advice if you have heavy menstrual bleeding.
Do not ignore symptoms such as persistent fatigue or dizziness.
Take supplements only when recommended by a healthcare professional.
Follow prenatal care recommendations during pregnancy.

When Should You See a Doctor?

You should arrange a medical evaluation if you experience:

Persistent fatigue lasting several weeks
Unexplained weakness
Shortness of breath with minimal activity
Dizziness or fainting
Pale skin
Blood in the stool, urine, or vomit
Black, tarry stools
Heavy menstrual bleeding
Chest pain or a rapid heartbeat associated with symptoms of anemia

Seek emergency medical care immediately if you have severe shortness of breath, chest pain, collapse, or signs of significant bleeding.

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